An intracerebral beta microprobe for studying radiotracer kinetics in freely moving animals

Author

Woody, C.L. ; Stol, S.P. ; Schlyer, D.J. ; Shokouhi, S. ; Gerasimov, M. ; Dewey, S. ; Volkow, N.

Author_Institution

Brookhaven Nat. Lab., Upton, NY, USA

Volume

3

fYear

2000

fDate

2000

Abstract

A scintillation microprobe has been developed to directly measure the positron decay activity from radiotracers in live animals. The probe consists of a small LSO crystal coupled to an optical fiber which is read out with a photomultiplier tube operated in a single photon counting mode. Positron conversions in the crystal are detected with high efficiency due to the excellent stopping power and high light output of LSO, and allows for the direct determination of the positron emitter concentration in a localized region of tissue. The probe can be used in the study of chemical kinetics and the development of new radiotracers in awake and freely moving animals

Keywords

beta-ray detection; biological techniques; brain; optical fibre couplers; photomultipliers; probes; awake animals; biological research instrumentation; chemical kinetics; freely moving animals; intracerebral beta microprobe; light output; localized tissue region; new radiotracers development; positron decay activity measurement; positron emitter concentration; radiotracer kinetics study; scintillation microprobe; small LSO crystal; stopping power; Animals; Chemicals; Kinetic theory; Optical coupling; Optical fibers; Photomultipliers; Photonic crystal fibers; Photonic crystals; Positrons; Probes;

fLanguage

English

Publisher

ieee

Conference_Titel

Nuclear Science Symposium Conference Record, 2000 IEEE

Conference_Location

Lyon

ISSN

1082-3654

Print_ISBN

0-7803-6503-8

Type

conf

DOI

10.1109/NSSMIC.2000.949352

Filename

949352