Title :
An intracerebral beta microprobe for studying radiotracer kinetics in freely moving animals
Author :
Woody, C.L. ; Stol, S.P. ; Schlyer, D.J. ; Shokouhi, S. ; Gerasimov, M. ; Dewey, S. ; Volkow, N.
Author_Institution :
Brookhaven Nat. Lab., Upton, NY, USA
Abstract :
A scintillation microprobe has been developed to directly measure the positron decay activity from radiotracers in live animals. The probe consists of a small LSO crystal coupled to an optical fiber which is read out with a photomultiplier tube operated in a single photon counting mode. Positron conversions in the crystal are detected with high efficiency due to the excellent stopping power and high light output of LSO, and allows for the direct determination of the positron emitter concentration in a localized region of tissue. The probe can be used in the study of chemical kinetics and the development of new radiotracers in awake and freely moving animals
Keywords :
beta-ray detection; biological techniques; brain; optical fibre couplers; photomultipliers; probes; awake animals; biological research instrumentation; chemical kinetics; freely moving animals; intracerebral beta microprobe; light output; localized tissue region; new radiotracers development; positron decay activity measurement; positron emitter concentration; radiotracer kinetics study; scintillation microprobe; small LSO crystal; stopping power; Animals; Chemicals; Kinetic theory; Optical coupling; Optical fibers; Photomultipliers; Photonic crystal fibers; Photonic crystals; Positrons; Probes;
Conference_Titel :
Nuclear Science Symposium Conference Record, 2000 IEEE
Conference_Location :
Lyon
Print_ISBN :
0-7803-6503-8
DOI :
10.1109/NSSMIC.2000.949352
