Title :
SAW based mass-loading biosensor for DNA detection
Author :
Hualin Cai ; Changjian Zhou ; Yihan Zhang ; Yi Yang ; Tianling Ren ; Cangran Guo ; Jing Liu
Author_Institution :
Inst. of Microelectron., Tsinghua Univ., Beijing, China
Abstract :
In this paper, a Surface Acoustic Wave (SAW) biosensor with gold coated delay area detecting DNA sequences is proposed. By well-designed procedures of device structure and parameters, we manufactured a simple and high-performance SAW on LiNbO3 substrate. The SAW biosensor with gold delay area that is connected to PCB board through bonding wires could be used for the direct measurement and sonic path comparative measurement of S11 parameter by using Network Analyzer. The device works near 65MHz. The loading mass of DNA probe and target DNA sequences are obtained from frequency shift, which is big enough in this work due to an effective biological treatment method. The testing result shows that the SAW sensor has a high sensitivity of 1.2pg/ml/Hz.
Keywords :
DNA; bioacoustics; biosensors; gold; lithium compounds; molecular biophysics; network analysers; printed circuits; surface acoustic wave sensors; Au; DNA detection; DNA probe; LiNbO3; LiNbO3 substrate; Network Analyzer; PCB board; S11 parameter; SAW based mass-loading biosensor; biological treatment method; bonding wire; device parameter; device structure; frequency 65 MHz; frequency shift; gold coated delay area; high-performance SAW; sensor sensitivity; sonic path comparative measurement; surface acoustic wave biosensor; target DNA sequences; Biosensors; Bonding; DNA; Educational institutions; Sensitivity; Surface acoustic waves; Wires; DNA detection; SAW sensor; high sensitivity;
Conference_Titel :
Electron Devices and Solid-State Circuits (EDSSC), 2013 IEEE International Conference of
Conference_Location :
Hong Kong
DOI :
10.1109/EDSSC.2013.6628122
