SAW based mass-loading biosensor for DNA detection

Author

Hualin Cai ; Changjian Zhou ; Yihan Zhang ; Yi Yang ; Tianling Ren ; Cangran Guo ; Jing Liu

Author_Institution

Inst. of Microelectron., Tsinghua Univ., Beijing, China

fYear

2013

fDate

3-5 June 2013

Firstpage

1

Lastpage

2

Abstract

In this paper, a Surface Acoustic Wave (SAW) biosensor with gold coated delay area detecting DNA sequences is proposed. By well-designed procedures of device structure and parameters, we manufactured a simple and high-performance SAW on LiNbO₃ substrate. The SAW biosensor with gold delay area that is connected to PCB board through bonding wires could be used for the direct measurement and sonic path comparative measurement of S₁₁ parameter by using Network Analyzer. The device works near 65MHz. The loading mass of DNA probe and target DNA sequences are obtained from frequency shift, which is big enough in this work due to an effective biological treatment method. The testing result shows that the SAW sensor has a high sensitivity of 1.2pg/ml/Hz.

Keywords

DNA; bioacoustics; biosensors; gold; lithium compounds; molecular biophysics; network analysers; printed circuits; surface acoustic wave sensors; Au; DNA detection; DNA probe; LiNbO₃; LiNbO₃ substrate; Network Analyzer; PCB board; S11 parameter; SAW based mass-loading biosensor; biological treatment method; bonding wire; device parameter; device structure; frequency 65 MHz; frequency shift; gold coated delay area; high-performance SAW; sensor sensitivity; sonic path comparative measurement; surface acoustic wave biosensor; target DNA sequences; Biosensors; Bonding; DNA; Educational institutions; Sensitivity; Surface acoustic waves; Wires; DNA detection; SAW sensor; high sensitivity;

fLanguage

English

Publisher

ieee

Conference_Titel

Electron Devices and Solid-State Circuits (EDSSC), 2013 IEEE International Conference of

Conference_Location

Hong Kong

Type

conf

DOI

10.1109/EDSSC.2013.6628122

Filename

6628122