Title :
Estimating the Reliability of Protein-Protein Interactions
Author :
Park, Byungkyu ; Han, Kyungsook
Author_Institution :
Dept. of Comput. Sci. & Inf. Eng., Inha Univ., Incheon
Abstract :
Many methods developed for estimating the reliability of protein-protein interactions are based on the topology analysis of protein-protein interaction networks. This paper describes a new reliability measure of protein-protein interactions, which is theoretically rigorous, yet biologically meaningful. The new measure does not rely on the topology of protein interaction networks, but formulates the biological information on functional roles, sub-cellular localizations and protein classes into a theoretically rigorous scoring scheme. Comparison of the new measure with IG1, IG2, and IRAP shows that the new measure is better than IG1 and IG2, and slightly better than IRAP. The new measure will be useful for filtering many spurious interactions as well as for estimating the reliability of protein interaction data.
Keywords :
biochemistry; biology computing; cellular biophysics; molecular biophysics; proteins; IRAP; functional roles; interaction generality measure; interaction reliability; protein classes; protein-protein interactions; scoring scheme; subcellular localizations; Computer network reliability; Computer science; Filtering; Fungi; Information analysis; Information technology; Network topology; Protein engineering; Reliability engineering; Reliability theory;
Conference_Titel :
Frontiers in the Convergence of Bioscience and Information Technologies, 2007. FBIT 2007
Conference_Location :
Jeju City
Print_ISBN :
978-0-7695-2999-8
DOI :
10.1109/FBIT.2007.59