DocumentCode :
3477959
Title :
Signal Analysis of Pathogens´ Genomic Sequences
Author :
Cristea, Paul Dan ; Tuduce, Rodica ; Cornelis, Jan
Author_Institution :
Univ. Politeh. of Bucharest, Bucharest
fYear :
2007
fDate :
11-13 Oct. 2007
Firstpage :
245
Lastpage :
250
Abstract :
The conversion of symbolic nucleotide sequences into digital signals allows applying signal processing methods to the analysis of genomic data. The method reveals regularities in the distribution of nucleotides and pairs of nucleotides along the genomic sequences, that would be difficult to detect in symbolic form. The structural restrictions of genomic sequences are reflected in mathematical regularities easily noticeable in the corresponding genomic signals. This approach is also adequate for analyzing the variability of pathogens´ genomes, of individual genes, or of certain critical areas, to track the development of drug resistance. The paper presents results in the study of Mycobacterium tuberculosis (MT), with applications in faster diagnosis and in the elaboration of efficient treatment strategies.
Keywords :
cellular biophysics; diseases; drugs; genetics; medical signal processing; microorganisms; molecular biophysics; patient diagnosis; patient treatment; digital signals; disease diagnosis; drug resistance; genes; genomic sequences; genomic signals; mycobacterium tuberculosis; nucleotide sequences; nucleotides; pathogens; signal analysis; signal processing;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Frontiers in the Convergence of Bioscience and Information Technologies, 2007. FBIT 2007
Conference_Location :
Jeju City
Print_ISBN :
978-0-7695-2999-8
Type :
conf
DOI :
10.1109/FBIT.2007.102
Filename :
4524112
Link To Document :
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