Title :
The array of micro-reactor PCR chips and its control system
Author :
Li, Xianming ; Liu, Haifa
Author_Institution :
Sch. of Control Sci. & Eng., Shandong Univ., Jinan, China
Abstract :
A kind of low cost microreactor polymerase chain reaction (PCR) chips is designed in which there are no temperature sensor and heater, and a temperature control system to the array of this kind of chips is developed. The control system is composed of a unitized macroscopic control subsystem and a distributed microcosmic control subsystem. The temperature that PCR chips need is controlled approximately by unitized macroscopic subsystem in which water as heat medium is pumped through a special heat exchanger. An array of miniature heaters corresponding to the array of PCR chips is made in a flexible printed circuit board that provides temperature compensation to every PCR chip. To be composed a cascade control system and using statistical quality control (SPC) method, the temperature of every chip is controlled quickly and accurately by the miniature heaters cooperating together with the heat exchanger.
Keywords :
cascade control; compensation; distributed control; heat exchangers; lab-on-a-chip; microreactors; printed circuits; quality control; temperature control; PCR chip array; cascade control system; distributed microcosmic control subsystem; flexible printed circuit board; heat exchanger; heat medium; macroscopic control subsystem; microreactor polymerase chain reaction chip; miniature heater; statistical quality control method; temperature compensation; temperature control system; Control systems; Costs; Distributed control; Flexible printed circuits; Heat pumps; Polymers; Sensor arrays; Temperature control; Temperature sensors; Water heating; Cascade control; Microelectromechanical systems(MEMS); Polymerase chain reaction(PCR); Statistical quality control(SPC);
Conference_Titel :
Automation and Logistics, 2009. ICAL '09. IEEE International Conference on
Conference_Location :
Shenyang
Print_ISBN :
978-1-4244-4794-7
Electronic_ISBN :
978-1-4244-4795-4
DOI :
10.1109/ICAL.2009.5262598