DocumentCode
3480302
Title
Decay of sodium currents: second order kinetics in nerve membranes
Author
Sethumadhavan, H.G. ; Majumder, S.K. ; Venugopal, J.S.
Author_Institution
Central Food Tech. Res. Inst., Mysore, India
fYear
1988
fDate
4-7 Nov. 1988
Firstpage
1748
Abstract
The authors have worked out the kinetics of the sodium inactivation process by the application of voltage-clamp technique using AXOCLAMP-2A. Three measurements were made for the analysis and determination of kinetics of sodium current, namely time course of development of inactivation, time course of recovery from inactivation, and steady-state value of inactivation as a function of potential-revealed second-order kinetics not incorporated in the classical Hodgkin-Huxley equations for the h inactivation parameter.<>
Keywords
bioelectric phenomena; biomembrane transport; neurophysiology; AXOCLAMP-2A; Na/sup +/ currents; classical Hodgkin-Huxley equations; h inactivation parameter; nerve membranes; neurophysiology; second order kinetics; voltage-clamp technique;
fLanguage
English
Publisher
ieee
Conference_Titel
Engineering in Medicine and Biology Society, 1988. Proceedings of the Annual International Conference of the IEEE
Conference_Location
New Orleans, LA, USA
Print_ISBN
0-7803-0785-2
Type
conf
DOI
10.1109/IEMBS.1988.94969
Filename
94969
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