Title :
Molecular optical probes for imaging tumors
Author :
Achilefu, Samuel ; Bloch, Sharon ; Ye, Yunpeng ; Zhang, Zongren ; Dorshow, Richard ; Liang, Kexian
Author_Institution :
Washington Univ. Sch. of Med., St. Louis, MO, USA
Abstract :
Biomedical optical methods provide distinctly new diagnostic capabilities while complementing conventional imaging modalities. To be effective, the molecular probes should produce detectable, quantifiable and discernable signals in response to light absorption or biological activation. Presently, fluorescein, indocyanine green (ICG) and fluorescent photosensitizers are widely used as optical molecular probes for in vivo imaging of tumors, possibly due to their established photophysical properties and safety profile in humans.
Keywords :
biomedical optical imaging; cancer; light absorption; molecular biophysics; probes; tumours; ICG; biological activation; biomedical optical method; complementing conventional imaging modality; diagnostic capability; fluorescein; fluorescent photosensitizer; indocyanine green; light absorption; molecular optical probe; photophysical property; tumour in vivo imaging; Absorption; Biomedical imaging; Biomedical optical imaging; Fluorescence; Humans; In vivo; Neoplasms; Optical imaging; Probes; Safety;
Conference_Titel :
Biophotonics/Optical Interconnects and VLSI Photonics/WBM Microcavities, 2004 Digest of the LEOS Summer Topical Meetings
Print_ISBN :
0-7803-8306-0
DOI :
10.1109/LEOSST.2004.1338660
