Title :
Stokes shift spectroscopy for biomedical applications and bio-agent sensing
Author :
Katz, A. ; Alfano, R.R.
Author_Institution :
Dept. of Phys., City Coll. of New York, NY, USA
Abstract :
Stokes shift Spectroscopy (Sss) is a technique that combines excitation and emission spectroscopy to enhance the ability to identify fluorescence signatures when several biomolecules with overlapping spectra are present. Sss provides an improved method to measure the spectral fingerprints of fluorophores with broad emission bands in situations with large noise levels. In this work, the Sss technique was used in two different applications the detection of malignancy in tissues, and in situ sensing and monitoring of bio-agents (bacteria and viruses).
Keywords :
biosensors; cancer; fluorescence; microorganisms; molecular biophysics; spectroscopy; tumours; ultraviolet spectra; Stokes shift spectroscopy; bacteria; bio-agent monitoring; bio-agent sensing; biomedical application; biomolecule; broad emission band; emission spectroscopy; excitation spectroscopy; fluorescence signature; fluorophores; malignancy detection; noise level; spectral fingerprint; tissues; virus; Biomedical measurements; Fingerprint recognition; Fluorescence; Microorganisms; Molecular biophysics; Monitoring; Noise level; Noise measurement; Spectroscopy; Viruses (medical);
Conference_Titel :
Biophotonics/Optical Interconnects and VLSI Photonics/WBM Microcavities, 2004 Digest of the LEOS Summer Topical Meetings
Print_ISBN :
0-7803-8306-0
DOI :
10.1109/LEOSST.2004.1338661