Title :
Ultra sensitive and compact VCSEL-based biosensor for detection of protein interactions and dengue antibodies
Author :
Mateus, Carlos F R ; Huang, Michael C Y ; Parekh, Devang ; Chang-Hasnain, Connie J. ; Foley, Jonathan E. ; Lim, Wilfred O. ; Beatty, P. Robert ; Li, Peter ; Cunningham, Brian T.
Author_Institution :
Electr. Eng. & Comput. Eng. Dept., California Univ., Berkeley, CA, USA
Abstract :
We report a label-free biosensor system that consists of a tunable VCSEL, a plastic guided mode resonant filter and two pin detectors. The biosensor has´demonstrated the sensitivity of detecting antigen proteins concentration as low as Ipg/ml (6.7fM) and antibodies to dengue virus.
Keywords :
biosensors; microorganisms; optical filters; proteins; surface emitting lasers; biosensor system; compact VCSEL; dengue antibody; dengue virus; detecting antigen proteins concentration; pin detector; plastic guided mode resonant filter; protein interaction detection; ultra sensitive; Biosensors; Mice; Optical filters; Optical surface waves; Proteins; Resonance; Time measurement; Tunable circuits and devices; Vertical cavity surface emitting lasers; Wavelength measurement;
Conference_Titel :
Biophotonics/Optical Interconnects and VLSI Photonics/WBM Microcavities, 2004 Digest of the LEOS Summer Topical Meetings
Print_ISBN :
0-7803-8306-0
DOI :
10.1109/LEOSST.2004.1338664
