Title :
A general shape equation for local regular structure of biomolecular chains
Author :
Hong, Liu ; Lei, Jinzhi
Author_Institution :
Zhou Pei-Yuan Center for Appl. Math., Tsinghua Univ., Beijing, China
Abstract :
A general shape equation for the local regular structure of biomolecular chains at the equilibrium state is established. It predicts a general relationship between the structural curvature and torsion, which only concerns about the elastic property of the molecular chain, and is independent of variable conformations of real biomolecules. Solutions corresponding to α-helix and β-hairpin in proteins, helical DNA, as well as spiral molecules are discussed, which show a fairly well agreement with experimental data.
Keywords :
DNA; librational states; molecular biophysics; molecular configurations; proteins; biomolecular chain local regular structure; biomolecule conformations; equilibrium state; general shape equation; helical DNA; molecular chain elastic property; protein alpha-helix; protein beta-hairpin; spiral molecules; structural curvature; torsion; DNA; Equations; Mathematical model; Molecular biophysics; Proteins; Shape; Spirals;
Conference_Titel :
Systems Biology (ISB), 2011 IEEE International Conference on
Conference_Location :
Zhuhai
Print_ISBN :
978-1-4577-1661-4
Electronic_ISBN :
978-1-4577-1665-2
DOI :
10.1109/ISB.2011.6033146
