Effects of cancer cell metastatic potential on intracellular mechanics

Author

Goldstein, Diana ; Weihs, Daphne

Author_Institution

Fac. of Biomed. Eng., Technion - Israel Inst. of Technol., Haifa, Israel

fYear

2010

fDate

17-20 Nov. 2010

Abstract

Understanding the unique mechanical properties of living cells in general, and specifically those of metastatic cancer cells, can lead to major developments in treatment and prevention of diseases. We combine cell micromechanics measurements with cell biology techniques to elucidate the mechanical response of cells. We focus on cells with different metastatic potentials and their response to cytoskeletal perturbation. We have observed different mechanical responses to microtubule disruption in cells with different metastatic potential. The response was different as compared to each cell lines´ control, although the control cells exhibited similar mechanical behavior. Our results may provide a more quantitative measure for metastatic potential in cells, as compared to the common medical definition.

Keywords

biological organs; biomechanics; biomedical measurement; cancer; cellular biophysics; gynaecology; micromechanics; patient diagnosis; patient treatment; breast cancer cell metastatic potential; cell biology; cell line; cytoskeletal perturbation; differential diagnosis; intracellular micromechanics measurement; mechanical properties; microtubule disruption; optimal treatment timing; Atmospheric measurements; Biomedical measurements; Breast cancer; Morphology; Particle measurements; Probes;

fLanguage

English

Publisher

ieee

Conference_Titel

Electrical and Electronics Engineers in Israel (IEEEI), 2010 IEEE 26th Convention of

Conference_Location

Eliat

Print_ISBN

978-1-4244-8681-6

Type

conf

DOI

10.1109/EEEI.2010.5661964

Filename

5661964