DocumentCode
3492862
Title
Optical biosensors from chemical transduction by lectins and neural receptors
Author
Krull, Ulrich J. ; Brown, R. Stephen ; Vandenberg, Elaine T. ; Hougham, B.D.
Author_Institution
Dept. of Chem., Toronto Univ., Mississauga, Ont., Canada
fYear
1988
fDate
4-7 Nov. 1988
Firstpage
793
Abstract
Instrumentation for optrode development in an intrinsic configuration was demonstrated by fluorescence from pyrene-labeled concanavalin A absorbed to the surface of an optical fiber. A system showing sensitivity, high selectivity, and reversibility was derived from the fluorescence detection of acetylcholine receptor binding to agonist. Fluorescence enhancement was seen for systems where a fluorophore was nonspecifically labeled to the receptor/membrane structure and also where only the lipid was fluorescent.<>
Keywords
biological techniques and instruments; fibre optic sensors; agonist; chemical transduction; fluorescence; fluorophore; lectins; neural receptors; optical biosensors; optical fiber; optrode development instrumentation; pyrene-labeled concanavalin A;
fLanguage
English
Publisher
ieee
Conference_Titel
Engineering in Medicine and Biology Society, 1988. Proceedings of the Annual International Conference of the IEEE
Conference_Location
New Orleans, LA, USA
Print_ISBN
0-7803-0785-2
Type
conf
DOI
10.1109/IEMBS.1988.95045
Filename
95045
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