An in-vitro test system for electrochemical sensors

A computer system has been developed to automate the in-vivo evaluation of amperometric electrochemical sensors in unanesthetized, tethered rabbits. Subcutaneous glucose, oxygen and temperature are monitored. Continuous, simultaneous monitoring of eight animals for several weeks is possible. Data collection rates are adjustable up to once every five minutes. Blood sample withdrawal and intravenous injection are carried out manually through a remote access port with computer prompting. Blood chemistry results are entered via keyboard and merged with the database from the sensor outputs. This multiple, parallel testing with minimal personnel intervention has made in-vivo statistical analysis of experimental electrochemical sensors feasible.<>