Title :
A handheld, cell phone-based electrochemical biodetector
Author :
Lillehoj, P.B. ; Huang, Ming-Chun ; Ho, Chun-Min
Author_Institution :
Michigan State Univ., East Lansing, MI, USA
Abstract :
We present a handheld, biomolecular detector based on a cell phone platform. This prototype integrates a conventional smart phone with a custom electrical circuit and a microfluidic chip, which enables a portable, lightweight biodetection system. An electrochemical detection scheme is utilized, allowing for rapid (<; 20 min), high sensitivity, analytical measurements. As proof of concept, Plasmodium falciparum histidine-rich protein 2 (PfHRP2) was detected in buffer solution, with a lower limit of detection of 16 ng/mL. Based on its compact size and high performance characteristics, this cell phone biodetector is highly suitable for use in remote locations for multiple applications including disease diagnosis, water quality monitoring and pathogen/toxin detection.
Keywords :
bioMEMS; bioelectric phenomena; biological techniques; biology computing; biosensors; cellular biophysics; diseases; electrochemical sensors; microfabrication; microfluidics; microorganisms; molecular biophysics; portable instruments; proteins; smart phones; analytical measurements; biomolecular detector; buffer solution; cell phone platform; cell phone-based electrochemical biodetector; compact size; conventional smart phone; custom electrical circuit; disease diagnosis; high performance characteristics; lightweight biodetection system; low detection limit; microfluidic chip; pathogen-toxin detection; plasmodium falciparum histidine-rich protein 2; portable biodetection system; remote locations; water quality monitoring; Biomedical measurement; Cellular phones; Microfluidics; Proteins; Semiconductor device measurement; Substrates; Universal Serial Bus;
Conference_Titel :
Micro Electro Mechanical Systems (MEMS), 2013 IEEE 26th International Conference on
Conference_Location :
Taipei
Print_ISBN :
978-1-4673-5654-1
DOI :
10.1109/MEMSYS.2013.6474174