Title :
Centrifugal imprinting during vitrification (CIV) of collagen hydrogel for highly biocompatible 3D membrane scaffold
Author :
Ikeuchi, M. ; Ikuta, K.
Author_Institution :
Res. Center for Adv. Sci. & Technol., Univ. of Tokyo, Tokyo, Japan
Abstract :
This paper reports on a novel micro imprinting process “CIV” to realize 3-D vascular scaffold made of natural biological polymer. The process is performed by gradual vacuum evaporation of hydrogel on a template under centrifugal force ~500G. This process realizes 3D membrane micro/nano structures of extra cellular matrix polymer (e.g. collagen, elastin) with natural self-assembled fibrous structures kept as same as in vivo. The fabricated structure is highly suitable for cell culture scaffold in tissue engineering since no organic solvent or cross-linking reagent is used in CIV process.
Keywords :
biochemistry; biodegradable materials; biomedical materials; biomembranes; cellular biophysics; centrifugal casting; hydrogels; materials preparation; molecular biophysics; nanofabrication; nanomedicine; nanostructured materials; polymers; proteins; tissue engineering; vacuum deposition; vitrification; 3D membrane microstructures; 3D membrane nanostructures; 3D vascular scaffold; CIV process; biocompatible 3D membrane scaffold; cell culture scaffold; centrifugal force; centrifugal imprinting; collagen hydrogel; cross-linking reagent; elastin; extracellular matrix polymer; gradual vacuum evaporation; microimprinting process; natural biological polymer; natural self-assembled fibrous structures; organic solvent; tissue engineering; vitrification; Biomembranes; Blood; Fabrication; Force; Microchannel; Polymers; Tissue engineering;
Conference_Titel :
Micro Electro Mechanical Systems (MEMS), 2013 IEEE 26th International Conference on
Conference_Location :
Taipei
Print_ISBN :
978-1-4673-5654-1
DOI :
10.1109/MEMSYS.2013.6474235
