Title :
Workshop: Reconstructing the organization of cancer genomes
Author :
Oesper, Layla ; Raphael, Benjamin J.
Author_Institution :
Dept. of Comput. Sci. & Center for Comput. Mol. Biol., Brown Univ., Providence, RI, USA
Abstract :
We apply our algorithms to multiple datasets. We apply PREGO to ovarian carcinoma samples from The Cancer Genome Atlas (TCGA) [3] and and identify rearrangements consistent with known mechanisms of duplication such as tandem duplications and breakage/fusion/bridge (B/F/B) cycles.
Keywords :
bioinformatics; cancer; genomics; medical computing; molecular biophysics; PREGO algorithm; Paired-end Reconstruction of Genome Organization algorithm; TCGA; The Cancer Genome Atlas; breakage-fusion-bridge cycle; cancer genome organization reconstruction; duplication mechanism; ovarian carcinoma sample; rearrangement identification; tandem duplication; Bioinformatics; Cancer; DNA; Genomics; Organizations; Sequential analysis; Tumors; algorithms; cancer genomics; copy number aberrations; intra-tumor heterogeneity; structural variants;
Conference_Titel :
Computational Advances in Bio and Medical Sciences (ICCABS), 2013 IEEE 3rd International Conference on
Conference_Location :
New Orleans, LA
DOI :
10.1109/ICCABS.2013.6629237
