A hybrid adaptive control approach for drug delivery systems

The goal of this investigation is the development of an adaptive drug-delivery system for use in regulation of critical-care patients suffering from cardiac failure. Adaptive control algorithms are combined with expert-system techniques to maintain stable patient status within narrow physiological bounds despite large plant uncertainty. To this end, a hybrid controller is presented whose structure is adjusted by an expert system that attempts to match the best control scheme in accordance with the dynamic structure of the plant. An illustrative example is presented, demonstrating the improved performance provided by this hybrid control scheme.<>