Implantable drug delivery system to control arrhythmia

Author

Arzbaecher, Robert ; Bump, Thomas ; Jenkins, Janice ; Larsen, Janine ; Yurkonis, Charles

Author_Institution

Pritzker Inst. of Med. Eng., Illinois Inst. of Technol., Chicago, IL, USA

fYear

1988

fDate

4-7 Nov 1988

Firstpage

42

Lastpage

47

Abstract

The feasibility of automatic drug delivery in the treatment of cardiac arrhythmia has been studied. In its clinical implementation this system consists of a computerized bedside rhythm monitor connected to an intravenous pump. It has been demonstrated in animals and in patients that therapeutic drug levels in the blood are rapidly established. An implantable version of such a system has been developed and tested in the experimental laboratory. Atrial fibrillation in the dog is recognized, and a pharmacokinetically based infusion is automatically delivered. Conversion to normal sinus rhythm occurs within minutes

Keywords

cardiology; patient treatment; prosthetics; arrhythmia control; atrial fibrillation; computerized bedside rhythm monitor; dog; implantable drug delivery system; intravenous pump; normal sinus rhythm; pharmacokinetically based infusion; therapeutic drug levels; Animals; Automatic control; Blood; Computerized monitoring; Control systems; Drug delivery; Laboratories; Patient monitoring; Rhythm; System testing;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Engineering., Proceedings of a Special Symposium on Maturing Technologies and Emerging Horizons in

Conference_Location

New Orleans, LA

Type

conf

DOI

10.1109/MTEHBE.1988.26390

Filename

26390