Title :
Neuronal electrical activity, energy consumption and mitochondrial ATP restoration dynamics: A physiological based model for FMRI
Author :
Gafaniz, Rita ; Sanches, J. Miguel
Author_Institution :
Inst. for Syst. & Robotic, Inst. Super. Tecnico, Lisbon, Portugal
fDate :
March 30 2011-April 2 2011
Abstract :
fMRI is a widely used method to detect the activated brain regions due to a stimulus application. Commonly, it employs the BOLD contrast, which is based on the correlation between physiological function, energy metabolism and haemodynamics. However, the BOLD signal is weak and noisy, so that, an accurate mathematical model to describe the Haemodynamic Response Function (HRF) to activation is needed.
Keywords :
bioelectric phenomena; biomedical MRI; cellular biophysics; molecular biophysics; neurophysiology; BOLD contrast; activated brain regions; energy consumption; energy metabolism; fMRI; haemodynamic response function; haemodynamics; mathematical model; mitochondrial ATP restoration dynamics; neuronal electrical activity; physiological function; physiological-based model; stimulus application; Biochemistry; Blood flow; Equations; Mathematical model; Neurons; Poles and zeros; Regulators; BOLD; Neuro-Metabolic Model; fMRI;
Conference_Titel :
Biomedical Imaging: From Nano to Macro, 2011 IEEE International Symposium on
Conference_Location :
Chicago, IL
Print_ISBN :
978-1-4244-4127-3
Electronic_ISBN :
1945-7928
DOI :
10.1109/ISBI.2011.5872419
