Title :
Real-time continuous dielectrophoretic separation of malignant cells
Author :
Alazzam, Anas ; Roman, Dacian ; Nerguizian, Vahé ; Stiharu, Ion ; Bhat, Rama ; Yasmeen, Amber ; Al Moustafa, Ala-Eddin
Author_Institution :
Dept. of Mech. & Ind. Eng., Concordia Univ., Montreal, QC
Abstract :
The present design introduces an optimized version of a microfluidics chip that uses dielectrophoresis phenomenon as a method of separation of the abnormal cells from the blood stream. Negative and positive dielectrophoretic forces (DEP) generated by a non-uniform electric field are engaged to separate the normal blood cells from the malignant ones. By fine tuning the parameters of the electric field different types of abnormal cells are isolated.
Keywords :
biomedical equipment; cellular biophysics; electric fields; electrophoresis; haemodynamics; microfluidics; blood stream; dielectrophoresis phenomenon; dielectrophoretic forces; electric field; malignant cells; microfluidics chip; real-time continuous dielectrophoretic separation; Blood; Cancer; Cells (biology); Design optimization; Dielectrics; Dielectrophoresis; Frequency; Industrial engineering; Microfluidics; Nonuniform electric fields; bio-MEMS; cell separation; dielectrophoresis; lab-on-a-chip;
Conference_Titel :
Microsystems and Nanoelectronics Research Conference, 2008. MNRC 2008. 1st
Conference_Location :
Ottawa, Ont.
Print_ISBN :
978-1-4244-2920-2
Electronic_ISBN :
978-1-4244-2921-9
DOI :
10.1109/MNRC.2008.4683374
