Real-time continuous dielectrophoretic separation of malignant cells

Author

Alazzam, Anas ; Roman, Dacian ; Nerguizian, Vahé ; Stiharu, Ion ; Bhat, Rama ; Yasmeen, Amber ; Al Moustafa, Ala-Eddin

Author_Institution

Dept. of Mech. & Ind. Eng., Concordia Univ., Montreal, QC

fYear

2008

fDate

15-15 Oct. 2008

Firstpage

45

Lastpage

48

Abstract

The present design introduces an optimized version of a microfluidics chip that uses dielectrophoresis phenomenon as a method of separation of the abnormal cells from the blood stream. Negative and positive dielectrophoretic forces (DEP) generated by a non-uniform electric field are engaged to separate the normal blood cells from the malignant ones. By fine tuning the parameters of the electric field different types of abnormal cells are isolated.

Keywords

biomedical equipment; cellular biophysics; electric fields; electrophoresis; haemodynamics; microfluidics; blood stream; dielectrophoresis phenomenon; dielectrophoretic forces; electric field; malignant cells; microfluidics chip; real-time continuous dielectrophoretic separation; Blood; Cancer; Cells (biology); Design optimization; Dielectrics; Dielectrophoresis; Frequency; Industrial engineering; Microfluidics; Nonuniform electric fields; bio-MEMS; cell separation; dielectrophoresis; lab-on-a-chip;

fLanguage

English

Publisher

ieee

Conference_Titel

Microsystems and Nanoelectronics Research Conference, 2008. MNRC 2008. 1st

Conference_Location

Ottawa, Ont.

Print_ISBN

978-1-4244-2920-2

Electronic_ISBN

978-1-4244-2921-9

Type

conf

DOI

10.1109/MNRC.2008.4683374

Filename

4683374