Challenges in modelling biofluids in microchannels

Author

Xue, Xiangdong ; Patel, Mayur K. ; Bailey, Chris ; Kersaudy-Kerhoas, Maïwenn ; Desmulliez, Marc P Y

Author_Institution

Sch. of Comput. & Math. Sci., Univ. of Greenwich, London

fYear

2008

fDate

1-4 Sept. 2008

Firstpage

287

Lastpage

292

Abstract

This paper presents the challenges encountered in modelling biofluids in microchannels. In particular blood separation implemented in a T-microchannel device is analysed. Microfluids behave different from the counterparts in the microscale and a different approach has been adopted here to model them, which emphasize the roles of viscous forces, high shear rate performance and particle interaction in microscope. A T-microchannel design is numerically analysed by means of computational fluid dynamics (CFD) to investigate the effectiveness of blood separation based on the bifurcation law and other bio-physical effects. The simulation shows that the device can separate blood cells from plasma.

Keywords

bifurcation; bioMEMS; blood; cellular biophysics; computational fluid dynamics; microfluidics; T-microchannel device; bifurcation law; bio-physical effects; biofluids; blood cells; blood separation; computational fluid dynamics; microfluids; particle interaction; shear rate performance; viscous forces; Bifurcation; Biological system modeling; Blood; Cells (biology); Computational fluid dynamics; Computational modeling; Microchannel; Microfluidics; Plasma devices; Plasma simulation;

fLanguage

English

Publisher

ieee

Conference_Titel

Electronics System-Integration Technology Conference, 2008. ESTC 2008. 2nd

Conference_Location

Greenwich

Print_ISBN

978-1-4244-2813-7

Electronic_ISBN

978-1-4244-2814-4

Type

conf

DOI

10.1109/ESTC.2008.4684363

Filename

4684363