Title :
Biochemical interactions of low frequency pulsing electromagnetic fields on melanoma cells
Author :
Ryaby, J.T. ; Tannenbaum, S. ; Sy, J. ; Pilla, A.A.
Author_Institution :
Dept. of Orthopaedics, Mount Sinai Sch. of Med., New York, NY, USA
Abstract :
Electromagnetic field stimulation of melanoma cells can induce differentiation as monitored by tyrosinase activity in a manner similar to that observed with the normal physiological regulator, melanocyte stimulating hormone (MSH). Short-term exposure depresses cAMP and cAMP-dependent protein kinase (PKA) levels for up to 30 minutes. In addition, when PEMF is removed there is a rapid increase in cAMP and PKA levels. The increase appears to be the trigger for induction of differentiation. Results obtained with pertussis toxin indicate that the site of interaction of PEMF may be at the level of the GTP binding proteins which regulate the receptor-adenylate-cyclase complex.<>
Keywords :
biological effects of fields; biomolecular effects of radiation; cellular effects of radiation; EM field stimulation; GTP binding proteins; biochemical interactions; cAMP; cAMP-dependent protein kinase; differentiation; low frequency pulsing electromagnetic fields; melanoma cells; pertussis toxin; receptor-adenylate-cyclase complex; tyrosinase activity;
Conference_Titel :
Engineering in Medicine and Biology Society, 1988. Proceedings of the Annual International Conference of the IEEE
Conference_Location :
New Orleans, LA, USA
Print_ISBN :
0-7803-0785-2
DOI :
10.1109/IEMBS.1988.95247
