Title :
Source distribution in multicellular preparations
Author :
Henriquez, Craig S. ; Trayanova, Natalla ; Plonsey, Robert
Author_Institution :
Dept. of Biomed. Eng., Duke Univ., Durham, NC, USA
Abstract :
The electrical field generated by activity in a bundle of fibers can be viewed as arising from sources distributed throughout the cross-section. A model study is presented in which the source density is calculated at various depths in a circular, cylindrical bundle of cardiac tissue using expressions derived from a bidomain model. The results show that unlike the equivalent source density of a single fiber which is uniformly distributed in the cross-section, the source density distribution in the bundle is nonuniform. For large bundles (>4 mm), the magnitude of the source strength is greatest near the axis and decreases sharply within 250 mu m of the surface.<>
Keywords :
bioelectric potentials; cardiology; cellular biophysics; neurophysiology; physiological models; activity; bidomain model; cardiac tissue; circular cylindrical bundle; electrical field; fibre bundle; large bundles; multicellular preparations; source density; source distribution;
Conference_Titel :
Engineering in Medicine and Biology Society, 1988. Proceedings of the Annual International Conference of the IEEE
Conference_Location :
New Orleans, LA, USA
Print_ISBN :
0-7803-0785-2
DOI :
10.1109/IEMBS.1988.95272
