Title :
Using a cell manipulation biochip to investigate the adhesion characteristics of single mammalian cells
Author :
Cellere, G. ; Borgo, M. ; Toni, A. De ; Bandiera, L. ; Santoni, L. ; Biondato, L. ; Paccagnella, A. ; Lorenzelli, L.
Author_Institution :
Dept. of Inf. Eng., Univ. di Padova, Padova
Abstract :
Single cultured cells can be genetically modified with a silicon Multi Electrode Array which can locally and transiently break down the cell membrane, allowing exogenous molecules to enter the cell. An accurate electrical model of the biochip-solution-cell system can be coupled to a statistical method in order to evaluate the probability of correctly detecting the presence (or absence) of a cell over a given electrode.
Keywords :
biocomputers; biocomputing; adhesion characteristics; biochip solution cell system; cell manipulation biochip; cell membrane; silicon multi electrode array; single cultured cell; single mammalian cell; Adhesives; Biomembranes; Cells (biology); Electrodes; Fluorescence; Immune system; Impedance; Microelectrodes; Silicon; Surface resistance;
Conference_Titel :
Ultimate Integration of Silicon, 2008. ULIS 2008. 9th International Conference on
Conference_Location :
Udine
Print_ISBN :
978-1-4244-1729-2
Electronic_ISBN :
978-1-4244-1730-8
DOI :
10.1109/ULIS.2008.4527169
