Title :
Effects of fluoride on the electrophysiological properties of heart cells and computer simulation
Author :
Chengde, Qin ; Yang, Hu ; Junlian, Wang ; Xiaoguang, Li
Author_Institution :
Dept. of Bioeng., Huazhong Univ. of Sci. & Technol., Wuhan, China
Abstract :
Using intracellular recording with a microelectrode, the authors studied the changes of heart-cell action potentials after administration of fluoride. The same results were obtained in various kinds of heart cells, including atrial, ventricular, sino-atrial node, Purkinje fiber, cultured myocardial, and ventricular cells in situ. Simulation analysis based on these results suggests that fluoride can block the sodium channel, activate the potassium channel and block the calcium channel.<>
Keywords :
bioelectric potentials; cardiology; cellular transport and dynamics; digital simulation; Ca channel; K channel; Na channel; Purkinje fiber; computer simulation; cultured myocardial cells; electrophysiological properties; fluoride administration atrial cells; fluoride effects; heart cells; heart-cell action potentials; intracellular recording; microelectrode; sino atrial node cells; ventricular cells;
Conference_Titel :
Engineering in Medicine and Biology Society, 1988. Proceedings of the Annual International Conference of the IEEE
Conference_Location :
New Orleans, LA, USA
Print_ISBN :
0-7803-0785-2
DOI :
10.1109/IEMBS.1988.95285
