A polynomial design approach to robust control of neuromuscular blockade of patients subject to general anesthesia

This work addresses the design of robust controllers for the neuromuscular blockade (NMB) level of patients subject to general anesthesia. The approach followed relies on the design of pole-placement controllers using input-output models and polynomial techniques. Robust performance is imposed in the NMB control design in order to perform appropriate responses on the model database. Robust stability is required in the design for the controller to be able to tackle the uncertainty present in these biomedical systems. Clinical results with the resulting controller are presented.