Title :
A Method for Improving the Accuracy of Predicting Protein Structural Classes
Author :
Wang, Tong ; Wang, Anbao ; Hu, Lihua
Author_Institution :
Inst. of Comput. & Inf., Shanghai Second Polytech. Univ., Shanghai, China
Abstract :
The structure of a protein is closely correlated to its function. Feature dimension reduction method is one of most famous machine learning tools. Some researchers have begun to explore feature dimension reduction method for computer vision problems. Few such attempts have been made for classification of high-dimensional protein data sets. In this paper, feature dimension reduction method is employed to reduce the size of the features space. Comparison between linear Feature dimension reduction method and nonlinear feature dimension reduction method is performed to predict protein structural classes. The results with high success rates indicate that the above method is used effectively to deal with this complicated problem of predicting proteins structural classes.
Keywords :
bioinformatics; data reduction; learning (artificial intelligence); molecular configurations; proteomics; feature space size reduction; high dimensional protein data set classification; linear feature dimension reduction method; machine learning tools; nonlinear feature dimension reduction method; protein function; protein structural class prediction; protein structure; Accuracy; Amino acids; Covariance matrix; Kernel; Prediction algorithms; Principal component analysis; Proteins;
Conference_Titel :
Intelligent Systems and Applications (ISA), 2011 3rd International Workshop on
Conference_Location :
Wuhan
Print_ISBN :
978-1-4244-9855-0
Electronic_ISBN :
978-1-4244-9857-4
DOI :
10.1109/ISA.2011.5873418