Research progress of piezoelectric immunosensors

Piezoelectric immunosensor is a particular type of biosensor that utilizes the high mass sensibility of piezoelectric quartz crystal in conjunction with the high specificity of antigen-antibody immune reaction. It forms a kind of automated analysis and detection sensors and can make real-time detection for the antigen-antibody reactions on the surface of crystal blank. It is promoting immune diagnosis method to develop toward quantification. The piezoelectric immunosensor, which is especially suitable for the clinic laboratory diagnosis, is becoming one of the novel and attractive hot researches in the field of biomedical. In this paper, the fundamental principle and basic structure of piezoelectric immunosensor were briefly introduced, and the characteristics of existing piezoelectric immunosensor were discussed. The key technology of piezoelectric immune system was presented in detail. In addition, the existing problems in its application were summarized and the prediction on its future development direction was also made.