• DocumentCode
    3525142
  • Title

    Electroporation - How different length and shaped electrical pulses affect the permeability of cells

  • Author

    Daly, Keith ; Chen, George

  • Author_Institution
    Sch. of Electron. & Comput. Sci., Southampton Univ.
  • fYear
    2006
  • fDate
    15-18 Oct. 2006
  • Firstpage
    353
  • Lastpage
    356
  • Abstract
    Studies into electroporation have grown increasingly popular over the past few years; many studies have been presented both theoretically and practically based. Now presented is a numerical simulation study of the applied pulse amplitude, duration and shape and how these factors relate to the number of pores created during this process. Pulse shapes studied include rectangular, exponential and triangular pulses. Results suggest that out of the most common pulse shapes rectangular pulses are the most efficient pore producers, these results agree with prior studies however disagree with one study, which uses the same model for simulation.
  • Keywords
    cellular biophysics; permeability; porosity; cell permeability; electrical pulses; electroporation; Biological system modeling; Biomembranes; Computer science; Dielectrics and electrical insulation; Mathematical model; Numerical simulation; Permeability; Protection; Pulse shaping methods; Shape;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Electrical Insulation and Dielectric Phenomena, 2006 IEEE Conference on
  • Conference_Location
    Kansas City, MO
  • Print_ISBN
    1-4244-0546-7
  • Electronic_ISBN
    1-4244-0547-5
  • Type

    conf

  • DOI
    10.1109/CEIDP.2006.311942
  • Filename
    4105443