• DocumentCode
    3530815
  • Title

    Spintronic biosensors for gene or micro-organism detection

  • Author

    Freitas, P.P. ; Ferreira, H. ; Graham, D. ; Feliciano, N. ; Carias, C. ; Ferreira, R. ; Clarke, L. ; Amaral, M. ; Galvin, P. ; Martins, V. ; Fonseca, L. ; Cabral, J.S.

  • Author_Institution
    INESC Microsyst. & Nanotechnol., Lisbon, Portugal
  • fYear
    2005
  • fDate
    4-8 April 2005
  • Firstpage
    515
  • Abstract
    Spintronic biosensors are integrated microchips where arrays of biological probes (DNA, antibodies) are immobilized over a functionalized surface, and arrays of magnetoresistive sensors are used to detect the eventual hybridisation of magnetically labelled complementary target biomolecules (complementary DNA, antigens) to the immobilized probes. Non-remnant magnetic beads with diameters, ranging from few microns to few hundred nanometers are used to label the target biomolecules. The magnetically labelled target biomolecules can then be efficiently concentrated over the probe areas by using on-chip generated local magnetic field gradient. Here, the first statistical data obtained with cystic fibrosis related probes and targets is discussed. Also, a second biological assay using Salmonella cells and antibodies is also discussed.
  • Keywords
    DNA; biomagnetism; biosensors; cellular biophysics; genetics; magnetic particles; magnetoelectronics; magnetoresistive devices; molecular biophysics; DNA; Salmonella cells; antibodies; antigens; biological assay; biological probes; cystic fibrosis related probes; gene detection; immobilized probes; integrated microchips; magnetically labelled complementary target biomolecules; magnetoresistive sensors; microorganism detection; nonremnant magnetic beads; on-chip generated local magnetic field gradient; spintronic biosensors; Biosensors; Cells (biology); DNA; Magnetic fields; Magnetic sensors; Magnetoelectronics; Magnetoresistance; Molecular biophysics; Probes; Sensor arrays;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Magnetics Conference, 2005. INTERMAG Asia 2005. Digests of the IEEE International
  • Print_ISBN
    0-7803-9009-1
  • Type

    conf

  • DOI
    10.1109/INTMAG.2005.1463686
  • Filename
    1463686