DocumentCode
3530815
Title
Spintronic biosensors for gene or micro-organism detection
Author
Freitas, P.P. ; Ferreira, H. ; Graham, D. ; Feliciano, N. ; Carias, C. ; Ferreira, R. ; Clarke, L. ; Amaral, M. ; Galvin, P. ; Martins, V. ; Fonseca, L. ; Cabral, J.S.
Author_Institution
INESC Microsyst. & Nanotechnol., Lisbon, Portugal
fYear
2005
fDate
4-8 April 2005
Firstpage
515
Abstract
Spintronic biosensors are integrated microchips where arrays of biological probes (DNA, antibodies) are immobilized over a functionalized surface, and arrays of magnetoresistive sensors are used to detect the eventual hybridisation of magnetically labelled complementary target biomolecules (complementary DNA, antigens) to the immobilized probes. Non-remnant magnetic beads with diameters, ranging from few microns to few hundred nanometers are used to label the target biomolecules. The magnetically labelled target biomolecules can then be efficiently concentrated over the probe areas by using on-chip generated local magnetic field gradient. Here, the first statistical data obtained with cystic fibrosis related probes and targets is discussed. Also, a second biological assay using Salmonella cells and antibodies is also discussed.
Keywords
DNA; biomagnetism; biosensors; cellular biophysics; genetics; magnetic particles; magnetoelectronics; magnetoresistive devices; molecular biophysics; DNA; Salmonella cells; antibodies; antigens; biological assay; biological probes; cystic fibrosis related probes; gene detection; immobilized probes; integrated microchips; magnetically labelled complementary target biomolecules; magnetoresistive sensors; microorganism detection; nonremnant magnetic beads; on-chip generated local magnetic field gradient; spintronic biosensors; Biosensors; Cells (biology); DNA; Magnetic fields; Magnetic sensors; Magnetoelectronics; Magnetoresistance; Molecular biophysics; Probes; Sensor arrays;
fLanguage
English
Publisher
ieee
Conference_Titel
Magnetics Conference, 2005. INTERMAG Asia 2005. Digests of the IEEE International
Print_ISBN
0-7803-9009-1
Type
conf
DOI
10.1109/INTMAG.2005.1463686
Filename
1463686
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