A CMOS-Compatible Biological Transducer for Creatinine Detection: MIP-Gate ISFET

Author

Lin, Chen-Fu ; Tsai, Hann-Huei ; Juang, Ying-Zong ; Su, Yan-Kuin ; Li, Wang-Long ; Wang, Ruey-Lue ; Lin, Hung-Yin ; Guo, Jia-Yu ; Tsai, Tian-Jun ; Liu, Bin-Da

Author_Institution

Nat. Chip Implementation Center, Nat. Appl. Res. Labs., Hsinchu

fYear

2009

fDate

28-29 April 2009

Firstpage

1

Lastpage

4

Abstract

In this paper, it demonstrates a CMOS-compatible transducer for creatinine detection. Different with traditional application of ISFET (Ion Selective Field Effect Transistor), it is not for the hydrogen ion detection. To combine the CMOS MEMS platform with MIP (Molecular Imprinting Polymer) micro coating technologies, the developed MlP-gate ISFET could be used for the detecting of creatinine. The experiment results showed that the difference of response current was about 13? A when the concentration was varied from 0.199 mg/mL to 0.787 mg/mL. Beside, this paper successfully demonstrates the possibility of the liquid isolation and localized MIP coating technology.

Keywords

CMOS integrated circuits; biomedical transducers; biosensors; coating techniques; ion sensitive field effect transistors; micromechanical devices; polymers; CMOS-compatible biological transducer; MEMS platform; MlP-gate ISFET; creatinine detection; ion selective field effect transistor; liquid isolation; microcoating technologies; molecular imprinting polymer; Biomembranes; Biosensors; CMOS process; CMOS technology; Chemical transducers; Coatings; Hydrogen; MOSFET circuits; Micromechanical devices; Polymers;

fLanguage

English

Publisher

ieee

Conference_Titel

Testing and Diagnosis, 2009. ICTD 2009. IEEE Circuits and Systems International Conference on

Conference_Location

Chengdu

Print_ISBN

978-1-4244-2587-7

Type

conf

DOI

10.1109/CAS-ICTD.2009.4960739

Filename

4960739