Surface modification of superparamagnetic iron oxide nanoparticles for clinical applications

Author

Woo, K. ; Hong, Jonggi

Author_Institution

Nano-Materials Res. Center, Korea Inst. of Sci. & Technol., Seoul, South Korea

fYear

2005

fDate

4-8 April 2005

Firstpage

799

Lastpage

800

Abstract

Monodisperse superparamagnetic iron oxide nanoparticles (SPIONs) were prepared by thermal decomposition of Fe(CO)₅ and by consecutive aeration in organic medium. The resultant hydrophobic SPION surface was modified to be hydrophilic via Fe-S covalent bond with bi-functional mercaptopropionic acid (MPA, HSCH₂CH₂COOH) and then, the terminal carboxylic acid group was esterified with dextran for biocompatibility. Analysis by water dispersity, TEM, XRD, and FT-IR is discussed.

Keywords

Fourier transform spectra; X-ray diffraction; infrared spectra; iron compounds; nanoparticles; nanotechnology; pyrolysis; superparamagnetism; surface treatment; transmission electron microscopy; FTIR; Fe₂O₃; TEM; XRD; aeration; bifunctional mercaptopropionic acid; biocompatibility; dextran; monodisperse superparamagnetic iron oxide nanoparticles; surface modification; terminal carboxylic acid group; thermal decomposition; water dispersity; Bonding; Iron; Nanoparticles; Polymers; Protection; Stability; Thermal decomposition; Virtual manufacturing; Water; X-ray scattering;

fLanguage

English

Publisher

ieee

Conference_Titel

Magnetics Conference, 2005. INTERMAG Asia 2005. Digests of the IEEE International

Print_ISBN

0-7803-9009-1

Type

conf

DOI

10.1109/INTMAG.2005.1463828

Filename

1463828