Automatic recognition and separation of touching and overlapping chromosomes

Author

Arezoo, Karimizadeh ; Payman, Moallem ; Mohammadreza, Yazdchi

Author_Institution

Dept. of Biomed. Eng., Univ. of Isfahan, Isfahan, Iran

fYear

2011

fDate

14-16 Dec. 2011

Firstpage

264

Lastpage

267

Abstract

Today, Karyotype analysis is frquently used in cytogenetics. it is time-consuming and repetitive, so an automatic analysis can greatly be valued. In this reasearch, an automatic method is presented. it first uses the geometric shape of the clusters to devide them into single chromosomes and clusters with more than one chromosome. Then each cluster is investigated to find the dark paths in touching chromosomes and geometric shapes to separate overlapping ones. A criterion function decides about similarity between the outputs and the single chromosomes and the best one is chosen. precision of this method in recognition of clusters with more than one chromosome is 75% and in separation of touching and overlapping ones are 74% and 66% respectively.

Keywords

biological techniques; biology computing; cellular biophysics; image processing; automatic analysis; automatic recognition; automatic separation; cluster geometric shape; criterion function; cytogenetics; karyotype analysis; overlapping chromosomes; touching chromosomes; Biomedical engineering; Conferences; Overlapping chromosomes; Touching chromosomes; dark path;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Engineering (ICBME), 2011 18th Iranian Conference of

Conference_Location

Tehran

Print_ISBN

978-1-4673-1004-8

Type

conf

DOI

10.1109/ICBME.2011.6168569

Filename

6168569