Title :
Causal compressive sensing for gene network inference
Author :
Deng, Mo ; Emad, Amin ; Milenkovic, Olgica
Author_Institution :
Univ. of Illinois, Urbana-Champaign, Urbana, IL, USA
Abstract :
We propose a novel framework for studying causal inference of gene interactions using a combination of compressive sensing and Granger causality techniques. The gist of the approach is to discover sparse linear dependencies between time series of gene expressions via a Granger-type elimination method. The method is tested on the Gardner dataset for the SOS network in E. coli, for which both known and unknown causal relationships are discovered.
Keywords :
causality; compressed sensing; inference mechanisms; signal reconstruction; time series; E. coli; Gardner dataset; Granger causality technique; Granger-type elimination method; SOS network; causal compressive sensing; causal inference; gene network inference interaction; sparse linear dependency; time series; Amplitude modulation; Compressed sensing; Gene expression; Sensors; Testing; Time series analysis; Vectors; Compressive sensing; Gene Expression; Granger Causality; SOS Network;
Conference_Titel :
Statistical Signal Processing Workshop (SSP), 2012 IEEE
Conference_Location :
Ann Arbor, MI
Print_ISBN :
978-1-4673-0182-4
Electronic_ISBN :
pending
DOI :
10.1109/SSP.2012.6319797