Title :
ECF sigma factor-associated regulatory networks in Streptomyces colicolor A3(2)
Author :
Zhou, Zhan ; Li, Qi ; Tudyk, Julie ; Li, Yong-Quan ; Wang, Yufeng
Author_Institution :
Dept. of Biol., Univ. of Texas at San Antonio, San Antonio, TX, USA
Abstract :
Sigma factors play important roles in transcriptional regulation in bacteria. Streptomyces coelicolor, a soil bacterium which is best known for its production of a variety of antibiotics, possesses a sophisticated transcriptional machinery. Among 58 sigma factors identified in the genome, 44 are extra-cytoplasmic function (ECF) sigma factors, which coordinate cellular responses to external signals. In this paper, we report a comprehensive analysis of the protein-protein association networks involving these sigma factors. The discovery of new network components and interactions has shed lights on the mechanisms underlying stress responses and morphological differentiation.
Keywords :
bioinformatics; cellular biophysics; microorganisms; proteins; ECF sigma factor-associated regulatory networks; cellular responses; extra-cytoplasmic function; morphological differentiation; network components; network interactions; protein-protein association networks; soil bacterium; streptomyces colicolor A3(2); stress responses; transcriptional machinery; transcriptional regulation; Bioinformatics; Databases; Genomics; Microorganisms; Proteins; Silicon germanium; Stress; STRING; Streptomyces; extracytoplasmic function; gene regulatory network; protein-protein association; sigma factor;
Conference_Titel :
Genomic Signal Processing and Statistics (GENSIPS), 2011 IEEE International Workshop on
Conference_Location :
San Antonio, TX
Print_ISBN :
978-1-4673-0491-7
Electronic_ISBN :
2150-3001
DOI :
10.1109/GENSiPS.2011.6169475
