Title :
Determination of polydimethylsiloxane (silicon) concentration in turbid samples from Raman spectra
Author :
Durkin, A.J. ; Ediger, Marwood N. ; Pettit, G.H.
Author_Institution :
Center for Devices & Radiol. Health, FDA, Rockville, MD, USA
Abstract :
Summary form only given. Recent technological advances have enabled the application of optical diagnostic techniques to human tissue and has suggested application of optical spectroscopy to a variety of biomedical problems. This work is a preliminary investigation of detection and monitoring of polydimethylsiloxane (PDMS) leakage in human breast tissue using Raman spectroscopy. The objectives of this project have direct pertinence to the concerns of physicians and patients about silicone implant integrity. It is shown that the method of partial least squares (PLS) can be used to accurately determine PDMS concentrations from turbid sample spectra and does not require a priori information if a training set with known concentrations is available.
Keywords :
Raman spectroscopy; biomedical measurement; chemical variables measurement; health hazards; laser applications in medicine; least squares approximations; patient diagnosis; patient monitoring; silicones; spectrochemical analysis; turbidity; 632.8 nm; He-Ne laser; PDMS detection; PDMS monitoring; Raman spectra; biomedical problems; human breast tissue; human tissue; optical diagnostic techniques; optical spectroscopy; partial least squares; polydimethylsiloxane concentration; polydimethylsiloxane leakage; silicone implant integrity; training set; turbid samples; Biomedical monitoring; Biomedical optical imaging; Breast tissue; Humans; Implants; Leak detection; Patient monitoring; Raman scattering; Silicon; Spectroscopy;
Conference_Titel :
Lasers and Electro-Optics, 1996. CLEO '96., Summaries of papers presented at the Conference on
Conference_Location :
Anaheim, CA, USA
Print_ISBN :
1-55752-443-2
