Determination of polydimethylsiloxane (silicon) concentration in turbid samples from Raman spectra

Summary form only given. Recent technological advances have enabled the application of optical diagnostic techniques to human tissue and has suggested application of optical spectroscopy to a variety of biomedical problems. This work is a preliminary investigation of detection and monitoring of polydimethylsiloxane (PDMS) leakage in human breast tissue using Raman spectroscopy. The objectives of this project have direct pertinence to the concerns of physicians and patients about silicone implant integrity. It is shown that the method of partial least squares (PLS) can be used to accurately determine PDMS concentrations from turbid sample spectra and does not require a priori information if a training set with known concentrations is available.