Title :
Integrated optical computing: system-on-chip for surface plasmon resonance imaging
Author :
Johnston, Matthew M W ; Wilson, Denise M. ; Boosh, K.S. ; Cramer, Jeffrey
Author_Institution :
Dept. of Electr. Eng., Univ. of Washington, Seattle, WA, USA
Abstract :
This paper presents a photodetection system for surface plasmon resonance (SPR) sensing that integrates optical computing with each pixel, thus enabling optical regression processing for sensing biological and chemical agents. The focus of this effort has been to upgrade a previous, low resolution, proof-of-concept approach to system-on-chip refractive index detection by SPR based systems. The next generation chip presented here contains five more pixels and seven more bits of resolution than the original proof of concept system. A refractive index resolution of 0.0002 RI is possible with the system presented here, as opposed to 0.0010 RI for the previous hardware and 0.0005 RI for previous software-level processing of SPR data.
Keywords :
biomedical imaging; biosensors; optical computing; refractive index; surface plasmon resonance; system-on-chip; SPR sensing; biological agents; chemical agents; integrated optical computing; optical regression processing; photodetection system; refractive index detection; surface plasmon resonance imaging; system-on-chip; Biomedical optical imaging; Integrated optics; Optical computing; Optical imaging; Optical refraction; Optical sensors; Plasmons; Refractive index; Resonance; System-on-a-chip;
Conference_Titel :
Circuits and Systems, 2005. ISCAS 2005. IEEE International Symposium on
Print_ISBN :
0-7803-8834-8
DOI :
10.1109/ISCAS.2005.1465379
