Title :
Pulse modulation CMOS image sensor for bio-fluorescence imaging applications
Author :
Ohta, Jun ; Tokuda, Takashi ; Kagawa, Keiichiro ; Nunoshita, Masahiro ; Shiosaka, Sadao
Author_Institution :
Graduate Sch. of Mater. Sci., Ikoma, Japan
Abstract :
For wide dynamic range, compatibility with digital circuits, and low-voltage operation, the pulse modulation technique is suitable for an implanted bioimage sensor. We demonstrate bio-fluorescence imaging of the hippocampus in a sliced mouse brain using a pulse modulation-based image sensor. The sensor architecture and system configuration are discussed. In addition, we develop an imaging device for implantation into a mouse brain in order to measure the neural activity in the hippocampus. The device is composed of a pulse modulation image sensor with 128×128 pixels and a fiber illuminator on a polyimide substrate.
Keywords :
CMOS image sensors; biosensors; brain; fluorescence; pulse modulation; CMOS image sensor; bio-fluorescence imaging; fiber illuminator; hippocampus; implanted bioimage sensor; neural activity; polyimide substrate; pulse modulation; sliced mouse brain; Biosensors; CMOS image sensors; Digital circuits; Dynamic range; Hippocampus; Image sensors; Mice; Pixel; Pulse modulation; Sensor systems;
Conference_Titel :
Circuits and Systems, 2005. ISCAS 2005. IEEE International Symposium on
Print_ISBN :
0-7803-8834-8
DOI :
10.1109/ISCAS.2005.1465380
