DocumentCode :
3547074
Title :
Cell culture biochemical IC chip with cell-level biocompatibility
Author :
Inoue, Yoshinori ; Ikuta, Koji
Author_Institution :
Res. Center for Adv. Sci. & Technol., Univ. of Tokyo, Tokyo, Japan
fYear :
2012
fDate :
Jan. 29 2012-Feb. 2 2012
Firstpage :
788
Lastpage :
791
Abstract :
We have developed a new Biochemical IC (integrated circuit) chip capable of cell culture with 3D capillaries fabricated by microstereolithography. This chip set realizes a real total system from biological synthesis to biochemical analysis. Unlike conventional μ-TAS approach, our biochemical IC chip-set has whole functions such as a micro pump, an active valve and an optical monitor for real time monitoring and control. However, since conventional photo curable polymer is not biocompatible, this fundamental issue needs to be solved to realize cell culturing and further on applications. To overcome this issue, we developed a unique approach, which was high temperature heat treatment, and accomplished to fabricate the cell culture chip based on biochemical IC.
Keywords :
DNA; bioMEMS; biochemistry; biological techniques; cellular biophysics; chemical analysis; heat treatment; integrated circuits; lab-on-a-chip; micropumps; molecular biophysics; polymers; proteins; stereolithography; 3D capillaries; biochemical analysis; biochemical integrated circuit chip; biological synthesis; cell culture biochemical IC chip; cell-level biocompatibility; conventional photocurable polymer; high temperature heat treatment; micropump; microstereolithography; optical monitoring; real time monitoring; Atmosphere; Computer architecture; Heat treatment; Micromechanical devices; Microprocessors; Polymers;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Micro Electro Mechanical Systems (MEMS), 2012 IEEE 25th International Conference on
Conference_Location :
Paris
ISSN :
1084-6999
Print_ISBN :
978-1-4673-0324-8
Type :
conf
DOI :
10.1109/MEMSYS.2012.6170304
Filename :
6170304
Link To Document :
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