Integrated microfluidic oxygenator bundles for blood gas exchange in premature infants

Author

Rochow, Niels ; Wu, Wen-I ; Chan, Emily ; Nagpal, Dipen ; Fusch, Gerhard ; Selvaganapathy, P. Ravi ; Monkman, Shelley ; Fusch, Christoph

Author_Institution

Dept. of Pediatrics, Div. of Neonatology, McMaster Univ., Hamilton, ON, Canada

fYear

2012

fDate

Jan. 29 2012-Feb. 2 2012

Firstpage

957

Lastpage

960

Abstract

This paper reports the development of a low volume pumpless lung assist device (LAD) composed of a stack of microfluidic single oxygenators units (SOUs) connected in parallel. SOUs are comprised of a microfluidic vascular network (polydimethylsiloxane) and a gas-permeable polycarbonate (PC) membrane to enhance gas exchange between blood and ambient air. We report results from an in vitro test and the first performance test of the LAD in hypoxic newborn piglet in which we show an increase of up to 40% in peripheral oxygen saturation.

Keywords

bioMEMS; biomedical equipment; blood; lung; microfluidics; paediatrics; pneumodynamics; LAD; blood gas exchange; gas-permeable polycarbonate membrane; hypoxic newborn piglet; in-vitro test; integrated microfluidic oxygenator bundles; low volume pumpless lung assist device; microfluidic single oxygenator units; microfluidic vascular network; peripheral oxygen saturation; polydimethylsiloxane; premature infants; Biomembranes; Blood; Blood flow; Lungs; Microfluidics; Pediatrics; Performance evaluation;

fLanguage

English

Publisher

ieee

Conference_Titel

Micro Electro Mechanical Systems (MEMS), 2012 IEEE 25th International Conference on

Conference_Location

Paris

ISSN

1084-6999

Print_ISBN

978-1-4673-0324-8

Type

conf

DOI

10.1109/MEMSYS.2012.6170345

Filename

6170345