Statistical investigation of efficiency of the nanomagnetic particle steering in blood vessels

Magnetic drug targeting is one of the drug delivery approaches which introduced recently. This approach is used the micro or Nano particles to deliver the drug to special organ in body. In this paper, the efficiency investigation of the steering method which is one of the magnetic drug targeting methods is presented. The efficiency has been studied by statistical method using the numerical simulation results. Our study shows that particles diameter has an important effect on guiding the particles to the desire path in steering method. The guiding efficiency of the 48% to 56% (depends on the particle diameter) for each bifurcation was achieved. It has been discovered that low velocity of blood flow near the vessels walls and therefore sticking of the particles to the vessels is the reason of the low increase in efficiency. It also was confirmed that steering method guiding efficiency is improving compare to no-magnet method when the number of the bifurcation increasing and then efficiency improvement of 615% for steering 500nm particles in the vessels path with 10 bifurcations was achieved.