Title :
Active CMOS biochip for time-resolved fluorescence detection
Author :
Patounakis, George ; Shepard, K.L. ; Levicky, R.
Author_Institution :
Dept. of Electr. Eng., Columbia Univ., New York, NY, USA
Abstract :
This paper describes the design of an active CMOS biosensor array for fluorescence-based assays which enables time-gated, time-resolved fluorescence spectroscopy. The array is sensitive to photon densities as low as 1.15 × 108/cm2, has a dynamic range of over 74 dB, and has sub-nanosecond timing resolution. High sensitivity is achieved through subsampling and averaging.
Keywords :
CMOS integrated circuits; biosensors; fluorescence; medical signal detection; time resolved spectroscopy; active CMOS biochip; averaging; dynamic range; photon density; spectroscopy; subsampling; time resolved fluorescence detection; timing resolution; Biomedical optical imaging; Biosensors; Fluorescence; Laser excitation; Optical filters; Optical losses; Optical sensors; Photodiodes; Probes; Spectroscopy;
Conference_Titel :
VLSI Circuits, 2005. Digest of Technical Papers. 2005 Symposium on
Print_ISBN :
4-900784-01-X
DOI :
10.1109/VLSIC.2005.1469336
