Assignment of terminal penalties in controlling genetic regulatory networks

Author

Choudhary, Ashish ; Datta, Aniruddha ; Bittner, Michael L. ; Dougherty, Edward R.

Author_Institution

Dept. of Electr. Eng., Texas A&M Univ., College Station, TX, USA

fYear

2005

fDate

8-10 June 2005

Firstpage

417

Abstract

Probabilistic Boolean networks have been used to model inter-gene relationships and their dynamic behavior. Optimal control of such networks has been proposed by turning on or off individual genes. Though this problem was solved in an earlier work by using a dynamic programming algorithm, issues regarding the assignment of terminal penalties and selection of genes for intervention were not addressed. In this work, we provide an algorithm for assigning terminal penalties, taking long term uncontrolled behavior into account. We also discuss the possibility of using gene influence for pre selection of genes to be used for intervention. This is implemented for the popular WNT5A network.

Keywords

Boolean functions; biocontrol; dynamic programming; genetics; optimal control; probability; WNT5A network; dynamic behavior; dynamic programming; gene influence; gene selection; genetic regulatory network control; intergene relationship modeling; optimal control; probabilistic Boolean networks; terminal penalty assignment; Bioinformatics; Biological system modeling; Control systems; Cost function; Genetics; Genomics; Intelligent networks; Optimal control; Turning; Uncertainty;

fLanguage

English

Publisher

ieee

Conference_Titel

American Control Conference, 2005. Proceedings of the 2005

ISSN

0743-1619

Print_ISBN

0-7803-9098-9

Electronic_ISBN

0743-1619

Type

conf

DOI

10.1109/ACC.2005.1469971

Filename

1469971