Title :
A computational study of microscale flow and mass transport in vasculatized tumors
Author :
Nabil, Mahdi ; Zunino, Paolo ; Cattaneo, Laura
Author_Institution :
Dept. of Mech. Eng. & Mater. Sci., Univ. of Pittsburgh, Pittsburgh, PA, USA
Abstract :
We develop A computational finite element model to study microcirculation and drug delivery to tumors under drug bolus injection into the blood stream. The mathematical model is based on the fundamental laws of filtration and transport in biological tissues at the micro-scale level. The model consists of two separate regions. A network of vessels carrying blood flow (the capillaries), and the surrounding tissue (interstitial volume). A comparison of flow and mass transport in healthy and tumor tissue models is presented using four case studies with different physiological properties.
Keywords :
blood vessels; drug delivery systems; finite element analysis; haemodynamics; physiological models; tumours; biological tissues; blood flow; blood stream; computational finite element model; drug bolus injection; drug delivery system; fundamental laws; interstitial volume; mathematical model; microcirculation; microscale flow transport; microscale mass transport; physiological properties; tumor tissue models; vasculatized tumors; Biomedical engineering; Conductivity; Drugs; Equations; Fluids; Mathematical model; Tumors; drug delivery; microvascular environment; perfusion and mass transport;
Conference_Titel :
Biomedical Engineering (ICBME), 2014 21th Iranian Conference on
Print_ISBN :
978-1-4799-7417-7
DOI :
10.1109/ICBME.2014.7043887
