A computational study of microscale flow and mass transport in vasculatized tumors

Author

Nabil, Mahdi ; Zunino, Paolo ; Cattaneo, Laura

Author_Institution

Dept. of Mech. Eng. & Mater. Sci., Univ. of Pittsburgh, Pittsburgh, PA, USA

fYear

2014

Firstpage

23

Lastpage

28

Abstract

We develop A computational finite element model to study microcirculation and drug delivery to tumors under drug bolus injection into the blood stream. The mathematical model is based on the fundamental laws of filtration and transport in biological tissues at the micro-scale level. The model consists of two separate regions. A network of vessels carrying blood flow (the capillaries), and the surrounding tissue (interstitial volume). A comparison of flow and mass transport in healthy and tumor tissue models is presented using four case studies with different physiological properties.

Keywords

blood vessels; drug delivery systems; finite element analysis; haemodynamics; physiological models; tumours; biological tissues; blood flow; blood stream; computational finite element model; drug bolus injection; drug delivery system; fundamental laws; interstitial volume; mathematical model; microcirculation; microscale flow transport; microscale mass transport; physiological properties; tumor tissue models; vasculatized tumors; Biomedical engineering; Conductivity; Drugs; Equations; Fluids; Mathematical model; Tumors; drug delivery; microvascular environment; perfusion and mass transport;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Engineering (ICBME), 2014 21th Iranian Conference on

Print_ISBN

978-1-4799-7417-7

Type

conf

DOI

10.1109/ICBME.2014.7043887

Filename

7043887