Title :
Feature genes selection and classification with SVM for microarray data of lung tissue
Author :
Si-Hao Du ; Shun-Feng Su ; Jin-Tsong Jeng ; Chih-Ching Hsiao
Author_Institution :
Dept. of Electron. Eng., Nat. Taiwan Univ. of Sci. & Technol., Taipei, Taiwan
Abstract :
Microarray analysis had been became a widely used tool for disease detection. It used tens of thousands of genes that would be a huge computational problem. The proposed approach applied feature genes selection and classification with support vector machine (SVM) for the microarray data of lung tissue. Based on the proposed approach, feature genes could be finding out according to the epsilon-support vector regression (epsilon-SVR) and selection ranked genes from each class. Moreover, applied multi-class support vector classification (multi-class SVC), cross-validation and parameter search methods to acquire great prediction classification accuracy and less computing time. That is, the effective dimension reduction for finding out feature genes is an important process in the proposed approach. The results shows the feature genes which our purposed approach finding out could acquire great prediction classification accuracy.
Keywords :
lung; medical computing; regression analysis; search problems; support vector machines; SVM; computing time; cross-validation methods; dimension reduction; epsilon-SVR; epsilon-support vector regression; feature genes classification; feature genes selection; lung tissue; microarray data; multiclass SVC; multiclass support vector classification; parameter search methods; prediction classification accuracy; selection ranked genes; support vector machine; Accuracy; Bioinformatics; Cancer; Diseases; Lungs; Static VAr compensators; Support vector machines; Microarray; dimension reduction; epsilon-SVR; multi-class SVC;
Conference_Titel :
Soft Computing and Intelligent Systems (SCIS), 2014 Joint 7th International Conference on and Advanced Intelligent Systems (ISIS), 15th International Symposium on
DOI :
10.1109/SCIS-ISIS.2014.7044677