Computer-aided bone scaffold design: a biomimetic approach

Author

Starly, B. ; Gomez, C. ; Darling, A. ; Fang, Z. ; Lau, A. ; Sun, W. ; Lau, W. ; Bradbury, T. ; Youssef, A. ; Gaylo, C.

Author_Institution

Dept. of Mech. Eng. & Mech., Drexel Univ., Philadelphia, PA, USA

fYear

2003

Firstpage

172

Lastpage

173

Abstract

The design of 3D tissue scaffolds for tissue engineering application should, if possible, biomimic the complex hierarchy and structural heterogeneity of the replaced tissues. This is particularly true for the design of bone tissue replacement with matched spatial heterogeneity and mechanical properties to the replaced bone. This paper presents an image-based computer modeling approach for reconstruction, characterization, and biomimetic modeling and design of three-dimensional bone tissue replacement, including the outline of biomimetic modeling approach, reconstruction to CAD-based tissue anatomic representation, and the design and characterization of bone replacement.

Keywords

CAD; biological tissues; biomechanics; biomedical materials; biomimetics; bone; cellular biophysics; computerised tomography; medical image processing; orthopaedics; physiological models; reverse engineering; 3D tissue scaffolds; CAD-based tissue anatomic representation; CT images; biomimetic modeling; bone tissue replacement; complex hierarchy; computer-aided bone scaffold design; image-based computer modeling approach; matched spatial heterogeneity; mechanical properties; reconstruction; replaced tissues; reverse engineering software; structural heterogeneity; three-dimensional bone tissue replacement; tissue engineering; Biological system modeling; Biomimetics; Bone tissue; Design automation; Image reconstruction; Image segmentation; Mechanical factors; Shape; Sun; Tissue engineering;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 2003 IEEE 29th Annual, Proceedings of

Print_ISBN

0-7803-7767-2

Type

conf

DOI

10.1109/NEBC.2003.1216047

Filename

1216047