Bio-MEMS towards single-molecular characterization

Author

Fujita, Hiroyuki

Author_Institution

Center for Int. Res. on Micronano Mechatoronics, Univ. of Tokyo, Tokyo, Japan

fYear

2014

Abstract

MEMS devices, which are capable of handling fluids and objects as small as molecules, enabled bio analysis in the ultimate level of a single molecule. This review includes three recent developments: (1) Micromachined tweezers with sharp tips successfully captured a bundle of DNA molecules and allowed realtime observation of DNA degradation dynamics. (2) A rotational bio molecular motor was encapsulated in a fL-chamber. Exact correlation was obtained between rotational speed and ATP production/consumption. (3) A bio motor system, microtubules and kinesin, was reconstructed on a chip. The chip can distinguish normal and abnormal tau-proteins related to Alzheimer´s disease.

Keywords

DNA; bioMEMS; biological techniques; diseases; molecular biophysics; proteins; reviews; ATP production-consumption; Alzheimer´s disease; DNA degradation dynamics; DNA molecules; bioMEMS; bioanalysis; biomotor system; encapsulation; fL-chamber; kinesin; micromachined tweezers; microtubules; review; rotational biomolecular motor; single-molecular characterization; tau-proteins; DNA; Microfluidics; Micromechanical devices; Nanobioscience; Proteins; Radiation effects; Resonant frequency;

fLanguage

English

Publisher

ieee

Conference_Titel

Electron Devices Meeting (IEDM), 2014 IEEE International

Type

conf

DOI

10.1109/IEDM.2014.7047145

Filename

7047145