Title :
Wound dressing on the base of polymer nanocomposites
Author :
Uspenskaya, M.V. ; Ignatyeva, Ju A. ; Kasanov, K.N. ; Olekhnovich, R.O. ; Strelnikova, I.E.
Author_Institution :
Inst. Bioeng., ITMO Univ., St. Petersburg, Russia
Abstract :
A novel mineral-containing composition on the based superabsorbent polymer hydrogel network was synthesized through chemical crosslinking by radical copolymerization of acrylamide (AA) and acrylic acid (AAc), N,N´-methylene-bis-acrylamide (MBA) as crosslinker and OXRED system: ammonium persulfate - N,N,N´,N´-tetramethylethylenediamine (TMED) as initiator. The montmorillonite modified by silver particles was used as filler. Influence of filler dispersion, silver concentration, synthesis conditions of a polymeric matrix on sorption characteristics of wound coverings was studied. The water absorption capacity of the hydrogel was in the range of 150 - 200g/g after immersion in distilled water for 48 h. The enhanced thermal stability of the hydrogel composition was confirmed by thermogravimetric analysis (TGA). The structures of the copolymers were confirmed by FTIR. Furthermore, antimicrobial and prolonged actions of acrylic polymer nanocomposites with silver ions were studied. The results showed that the hydrogel mineral-containing composite could be considered as a potential wound-dressing material.
Keywords :
Fourier transform infrared spectra; antibacterial activity; biomedical materials; hydrogels; materials preparation; nanocomposites; nanomedicine; patient treatment; polymer blends; polymerisation; silver; thermal analysis; thermal stability; wounds; FTIR; N,N´-methylene-bis-acrylamide; N,N,N´,N´-tetramethylethylenediamine; OXRED system; TGA; TMED; acrylic acid; acrylic polymer nanocomposites; ammonium persulfate; antimicrobial actions; chemical crosslinking; copolymers; crosslinker; distilled water; enhanced thermal stability; filler dispersion; hydrogel composition; hydrogel mineral-containing composite; initiator; mineral-containing composition; montmorillonite; polymeric matrix; radical copolymerization; silver concentration; silver ions; silver particles; sorption characteristics; superabsorbent polymer hydrogel network; synthesis condition; thermogravimetric analysis; time 48 h; water absorption capacity; wound coverings; wound-dressing material; Biomedical engineering; Ions; Nanocomposites; Polymers; Silver; Wounds; Acrylamide; Acrylic Acid; Hydrogel; Montmorillonite; Nanocomposite; Radical polymerization; Sorption; Wound Dressing;
Conference_Titel :
Biomedical Engineering and Sciences (IECBES), 2014 IEEE Conference on
DOI :
10.1109/IECBES.2014.7047523
