Title :
Biocompatible implantable biofuel cell
Author :
El Ichi, Sarra ; Zebda, Abdelkader ; Alcaraz, Jean-Pierre ; Boucher, Francois ; Boutonnat, Jean ; Cinquin, Philippe ; Martin, Donald K.
Author_Institution :
TIMC-IMAG, UJF-Grenoble 1, Grenoble, France
Abstract :
The present work demonstrates the in vivo biocompatibility and operation of a biofuel cell enclosed by a chitosan membrane. The measured power output in the range of 6.2 to 20.7 μW cm-2 (applied current from 10 to 70 μA) indicated that glucose and oxygen can reach the enzymes in the 3D matrix without any need for a buffer solution in the implant or a hydration step. This is very important to simplify the preparation and sterilization steps, to avoid contamination and to favour the close communication between the device and body fluids. This optimized biofuel cell is now being applied to supplying power for a leadless pacemaker.
Keywords :
biochemistry; enzymatic fuel cells; enzymes; materials preparation; molecular biophysics; oxygen; pacemakers; polymer films; prosthetic power supplies; sterilisation (microbiological); sugar; surface contamination; 3D matrix; O2; applied current range; biocompatible implantable biofuel cell; biofuel cell optimization; chitosan membrane; contamination; current 10 muA to 70 muA; device-body fluid close communication; enclosed biofuel cell biocompatibility; enzyme; glucose; hydration step; implant buffer solution; in vivo biofuel cell biocompatibility; in vivo biofuel cell operation; leadless pacemaker power supply; power 6.2 muW to 20.7 muW; power output measurement; power output range; preparation; sterilization; Biochemistry; Biofuels; Carbon nanotubes; Electrodes; Films; In vivo; Sugar;
Conference_Titel :
Biomedical Engineering and Sciences (IECBES), 2014 IEEE Conference on
DOI :
10.1109/IECBES.2014.7047553
