• DocumentCode
    3565501
  • Title

    Improvement of Markov chain processes for mathematical optimization of cancer treatment

  • Author

    Sbeity, Hoda ; Younes, Rafic ; Jammal, Manar

  • Author_Institution
    Univ. de Versailles, Versailles, France
  • fYear
    2014
  • Firstpage
    71
  • Lastpage
    76
  • Abstract
    Biologists have uncovered some of the most basic mechanisms by which normal cells develop into cancerous tumors. These biological theories can be transformed into adequate mathematical models. For this reason, we attempt to study the evolution of cancer cells using the Markov Chain Processes. Based on Markov chain Processes, cancer chemotherapy will be applied on them to treat the disease. However, chemotherapy is a complex treatment mode that requires balancing the benefits of treating tumors using anti-cancer drugs with the adverse toxic side-effects caused by these drugs. Some methods of computational optimization, Genetic Algorithm (GA) in particular, have proven to be useful in helping to strike the right balance. The purpose of this paper is to put in place a strategy to solve an optimal problem to facilitate finding optimal chemotherapeutic treatments which cause the death of cancer and have fewer side effects based on a chemotherapy treatment defined by the oncologist.
  • Keywords
    Markov processes; cancer; cellular biophysics; drugs; genetic algorithms; patient treatment; tumours; Markov chain process improvement; anticancer drug; cancer cell evolution; cancer chemotherapy; cancer treatment mathematical optimization; cancerous tumor; computational optimization; genetic algorithm; mathematical model; optimal chemotherapeutic treatment; Cancer; Drugs; Markov processes; Mathematical model; Optimization; Sociology; Statistics;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Biomedical Engineering and Sciences (IECBES), 2014 IEEE Conference on
  • Type

    conf

  • DOI
    10.1109/IECBES.2014.7047599
  • Filename
    7047599